Hmm...if you are on a familiar road and you know it has no washouts or muddy sections or creeks of an as-yet undetermined depth of water I suppose you can go with 2WD as outlined above. If you are going 25-35 MPH on known roads, sure, why not?
However...if you are in uncharted territory and you are on a less than stellar road surface, maybe some ruts, muddy sections, water crossing or pooling on the surface and it has some ups and downs you expect ahead according to you map....and you don't feel comfortable doing 35 MPH on it....you may choose to chug along at 25 MPH and I see no reason under the circumstances to NOT use the 4WD because those are the very conditions it was designed to help give you traction on.
Then there is the snow factor...which may hide some of the obstacles I mentioned above....that sounds like you need to proceed with caution anyway unless you really do KNOW the road well! In that event, the 4WD will be a good idea as well since you won't be going 45 MPH there either.
The toss-up I think is also affected by how your rig is loaded....heavy on the rear axle? Near the GVWR for the truck? I agree that 4WD may give some people a false sense of security, but you have to use some degree of common sense in any situation based on your truck, the load and the road.
Always better to err on the side of good judgement and SLOW DOWN to begin with and using 4WD is beneficial (read your truck owners manual about it) and when all else fails, time to chain up!