There a few tight switchbacks and one turn in particular that I recall having to "suck it in" in my Toyota. It would be a tight squeeze for a F250, but not impassable, especially if you have a co-pilot that can get out and guide you through.
Also there is one off camber spot that leans you over to the passenger side pretty hard, but again, not impassable. Just gotta take it slow and watch for pullouts on your way up. We crossed paths with a 4Runner coming down Lippencot and it was a really tight squeeze to get by him.
Challenges aside, it is a great trail, incredibly scenic and worth the drive up.