I began using Delorme's Earthmate For Mobile app on my iPad2 because the subscription to it comes with the Inreach Explorer I bought last summer. It was a snap to start using and I like how easily it downloads detailed North American maps and how it interacts with the Explorer.
I was also happily surprised to see the Earthmate app works well with the iPad's built-in GPS receiver*. If you have the Explorer up, it uses the GPS signal from the Explorer. If not, it reads the iPad's GPS signal. That's very handy, particularly if you like to keep the Explorer in your pack and use the iPad in the truck. It's very nice to have a zoomable offline map of anything from the interstate highway system to backcountry two-track (and showing your position on it) in easy reach.
I don't try to use it as my only navigation aid. I use a Garmin Montana in Automotive mode for its routable street maps to get to the area and in Recreational mode (with 24K topo map cards) on the trail. (It also has a Marine mode for Bluecharts but I've not used it yet.)
Despite all the electronic aids, I also have paper maps of some sort when my wife is traveling with me. She LOVES to mark up the map or map-book page with our route as we go. And I've got to admit I like finding those long after the trip. Looking at them instantly brings back memories of the area, if not of the day we were there.
-OC
PS- Here's a Youtube clip with basic info about using the app:
* Note: wifi-only iPads don't have a GPS chip built in.